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Nanostructured drugs embedded into a polymeric matrix: Vinpocetine/PVP hybrids investigated by Debye function analysis

机译:嵌入聚合物基质中的纳米结构药物:通过德拜功能分析研究了长春西汀/ PVP杂合体

摘要

Microcrystalline vinpocetine, coground with cross-linked polyvinylpyrrolidone, affords hybrids containing nanosized drug nanocrystals, the size and size distributions of which depend on milling times and drug-to-polymer weight ratios. Using an innovative approach to microstructural characterization, we analyzed wide-angle X-ray total scattering data by the Debye function analysis and demonstrated the possibility to characterize pharmaceutical solid dispersions obtaining a reliable quantitative view of the physicochemical status of the drug dispersed in an amorphous carrier. The microstructural properties derived therefrom have been successfully employed in reconciling the enigmatic difference in behavior between in vitro and in vivo solubilityudtests performed on nanosized vinpocetine embedded in a polymeric matrix.
机译:与交联的聚乙烯吡咯烷酮共研磨的微晶长春西汀可提供含有纳米级药物纳米晶体的杂化物,其尺寸和大小分布取决于研磨时间和药物与聚合物的重量比。使用创新的微结构表征方法,我们通过Debye函数分析对广角X射线总散射数据进行了分析,并证明了表征药物固体分散体的可能性,从而获得了分散在无定形载体中的药物的理化状态的可靠定量视图。由其衍生的微结构性质已成功地用于调和对嵌入聚合物基质中的纳米级长春西汀进行的体外和体内溶解度测试的神秘行为差异。

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