Distribution of HLA (class I and class II) antigens in the native Dravidian Hindus of Tamil Nadu, South India

摘要

HLA - A, B, C, DR, DQ antigen profile of South Indian Tamil-speakingudHindus of Dravidian descent was studied. Phenotype. gene and haplotypeudfrequencies were calculated and compared with the literature. There was audcomplete lack of A23, A25 and A32 antigens in the sample presently monitored.udExcept for minor differences (higher incidence of Cw6 and DR10udantigens), the Dravidian Hindus show similarity to North Indio-Aryan andudother Hindu samples. The haplotypes A1, B17; A2, B5: A2, B51; A1, DR7;udB12, DR7; B13, DR2; B17, DR7; DR2, DQ1; DR3, DQ2; DR4, DQ3; DR5,udDQ3; DR7, DQ2; DR11, DQ3 show significant positive linkage disequilibriumudwhereas A1, DR2; DR2, DQ2; DR7, DQ1 were significant for negativeudlinkage disequilibrium in the Dravidian Hindus.