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Unobserved Factors Linking Functional Decline and Depression Among the Oldest Americans

机译:未观察到的因素将最老的美国人的功能衰退和抑郁联系起来

摘要

This study considers the dependence between functional decline and depression in a nationally representative sample of older Americans from the Survey on Assets and Health Dynamics among the Oldest Old (AHEAD) covering the years from 1993 to 2002. Previous research has shown that depression is a significant predictor of functional decline and, conversely, functional limitations lead to more depressive symptoms. While this cross-dependence is an established fact in the literature, relatively few prior papers formally modeled the association between functional decline and depression. In this paper, functional decline is defined as 2 or more limitations in 5 Activities of Daily Living (ADL) and 2 or more limitations in 5 Instrumental Activities of Daily Living (IADL) from the baseline to the last available follow-up interview. Depression is defined as 3 or more points on the 8-item Center for Epidemiological Studies Depression (CES-D) Scale over the same range of time. In the analytic sample of 5,470 oldest Americans, each of the three measures is initially estimated in the univariate probit model controlling for a rich set of available risk factors identified in the previous studies. Then it is argued that univariate probit models are incapable of capturing individual differences (for example, predisposition to both physical and emotional ill health) that may link functional decline and depression in the oldest Americans. Thus, a more advanced multivariate probit model is employed, and three discrete equations are estimated jointly. In this way, unmeasured factors specific to the individual will become part of the error terms, and statistically significant correlations in the variance matrix will indicate dependence between functional decline and depression. Estimation of multivariate probit model reveals substantial unobserved heterogeneity in the dynamics of ADLs, IADLs, and CES-D score over time. Thus, previous results based on univariate methods should be interpreted with caution.
机译:这项研究从1993年至2002年的美国老年人资产和健康动态调查(AHEAD)的全国代表性样本中,研究了功能下降与抑郁之间的依赖关系。以前的研究表明,抑郁是一种重要的疾病功能衰退的预测指标,反之,功能受限会导致更抑郁的症状。尽管这种相互依赖关系在文献中是一个既定事实,但相对较少的先前论文正式地对功能下降和抑郁之间的关联进行了建模。在本文中,功能下降的定义是从基线到上次可用的后续访谈,在5种日常生活活动(ADL)中有2个或更多限制,在5种日常生活工具活动(IADL)中2个或更多限制。在8个项目的流行病学研究中心的抑郁症(CES-D)量表中,在相同的时间范围内,抑郁症的定义为3分或更多。在5470名最年长的美国人的分析样本中,这三种测量方法中的每一种都是在单变量概率模型中初步估算的,该模型控制着先前研究中确定的丰富的可用风险因子。然后有人认为,单变量概率模型无法捕获可能将年龄最大的美国人的功能下降和抑郁联系在一起的个体差异(例如,对身体和情绪健康的易感性)。因此,采用了更高级的多元概率模型,并联合估计了三个离散方程。这样,特定于个体的无法测量的因素将成为误差项的一部分,并且方差矩阵中的统计显着相关性将指示功能下降和抑郁之间的依赖性。多元概率模型的估计表明,随着时间的推移,ADL,IADL和CES-D分数的动态变化中存在大量未观察到的异质性。因此,基于单变量方法的先前结果应谨慎解释。

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    Obrizan Maksym;

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  • 年度 2011
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