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Continuous granulation of pharmaceutical powder using a twin screw granulator

机译:使用双螺杆制粒机连续制粒药物粉末

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摘要

Twin screw extruder (TSE) has been studied extensively as a granulator because it allows continuous processing. Initial work was carried out by comparing the TSE with conventional granulator shows that the mechanism of TSE granulation is different from conventional granulation with the absence of the consolidation stage. PEPT was also utilised and it reveals that the flow stream of the material is not only due to the conveying capacity but also the granulator fill, in particularly for the 90o mixing zone which is believed to be a dispersion type of mechanism driven by the granulator fill gradient. Residence time distribution was measured and simulated by fitting the experimental data using a continuous stirred tank reactors model. The model describes the experimental curves reasonably well when a plug flow fraction was considered. Generally the mean residence time (MRT) of the system is proportional to the mixing zone angle and is inversely proportional to the screw speeds and flowrate. A study using the variance reduction ratio demonstrates that the TSE granulator used in the present study is able to remove the feed instability given that the ratio of the frequency of the input stream fluctuation to the MRT is high.
机译:双螺杆挤出机(TSE)作为制粒机已经得到了广泛的研究,因为它可以连续加工。通过比较TSE与常规制粒机进行的初步工作表明,在没有固结阶段的情况下,TSE制粒的机理与常规制粒不同。还利用了PEPT,它揭示了物料的流动不仅取决于输送能力,还取决于造粒机的填充物,特别是对于90o混合区,这被认为是由造粒机填充物驱动的分散型机构梯度。通过使用连续搅拌釜反应器模型拟合实验数据来测量和模拟停留时间分布。当考虑活塞流比时,该模型可以很好地描述实验曲线。通常,系统的平均停留时间(MRT)与混合区角度成正比,与螺杆速度和流量成反比。使用方差减少率的研究表明,鉴于输入流波动频率与MRT的比值很高,本研究中使用的TSE制粒机能够消除进料不稳定性。

著录项

  • 作者

    Lee Kai Teck;

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  • 年度 2013
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  • 原文格式 PDF
  • 正文语种 English
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