Odnos polimorfizma gena za vitamin-D receptor, alfa-1 lanac kolagena I i estrogeni receptor i koštane mase u bolesnika s hipertireozom The association of polymorphisms of the vitamin-D receptor gene, collagen type I alpha-1 gene and estrogen receptor gene and bone mineral density in patients with hyperthyroidism

摘要

Hyperthyroidism is a recognised risk factor for secondary osteoporosis. Little is known about the genetic origin of osteoporosis in patients with hyperthyroidism. This is the first study to examine the association between polymorphism of the VDR (TaqI), ERalpha (PvuII), COLIA1 (BalI) genes and BMD in premenopausal women with hyperthyroidism. This study comprised 45 premenopausal women, with the average age 40,4±7,7 years. The BMD was measured in using dual X-ray absorptiometry (DXA) in the L1-L4 region of the spine and femoral neck. Multivariate analysis found no significant correlation between polymorphisms of the 3 selected genes, individually or in combination, and BMD at the lumbar spine and femoral neck, and no correlation between polymorphisms and osteoporosis and osteopenia. A relationship was found between body mass index (BMI) and BMD at femoral neck in patients heterozygous for Taq1 polymorphism of the VDR gene and PvuII polymorphism of the ER gene, and homozygous for BalI polymorphism of the COL1AI. ----- CONCLUSION: A statistically significant association was not found between TaqI polymorphism of the VDR gene, PvuII polymorphism of the ERalpha gene and BalI polymorphism of the COLIA1 gene and BMD at the lumbar spine and femoral neck in hyperthyroid premenopausal women.