Razvojne promjene mediosagitalnog presjeka korpusa kalozuma kao pokazatelji perinatalnog rasta interhemisferičnih veza u mozgu čovjeka Developmental changes in the midsagittal are of the corpus callosum as indicators of perinatal growth of interhemispheric connections in humans

摘要

Corpus callosum is the biggest commissural pathway of the telencephalon, connecting theudmajority of neocortical areas, hence it is most complex in the human. Its importance in clinicaludresearch lies in the fact that the period of its most prominent development coincides with theudoccurence of hypoxic-ischemic lesions in preterm-born infants.udThe midsagittal area of the corpus callosum in humans goes through a specific change,udwhich is manifested by a pause in its growth. We have shown that the glial elements do notudrepresent a significant structural factor, which would contribute to the change in area of theudcorpus callosum. We are convinced that the area change is a result of the change in number anduddensity of axonal elements. In the period between 28 and 35 gestational weeks, the most likelyudcause is the translocation of the growth front from the midline. After 35 gestational weeks theuddescribed change in area is most likely a result of a combination of axonal element numberuddecrease and axonal diametar increase, and additionally myelination after birth.udOn rat callosal samples we showed that the relationship between axonal number andudaxonal midsagittal area is age-dependant, in the period from postnatal day zero to twelve. Highudproportion of growth cones in this period indicates that there is still a substantial ingrowth ofudaxons.udThe results of this study represent a strong foundation for future research of normaluddevelopment and pathological changes of the corpus callosum.