Chemoenzymatic Synthesis of ent-Neopinone

摘要

The present thesis describes the chemoenzymatic synthesis of ent-neopinone.The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation ofbromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction,aldol condensation and a 1,6-conjugate addition.