Reaction of Naphthoquinones with Substituted Nitromethanes. Facile Synthesis and antifungal activity of Naphtho2,3-disoxazole-4,9-diones

摘要

We report here a simple entry into naphtho[2,3-]isoxazole-4,9-dione system containing a EWG in position 3 using the readily available 2,3-dichloro-1,4-naphthoquinone and nitromethyl derivatives in the presence of base. Antifungal activity of synthesised naphthoquinones was evaluated against ATCC and PYCC reference strains of . The results suggest that the naphtho[2,3-]isoxazole-4,9-dione scaffold has the potential to be developed into novel and safe therapeutic antifungal agents.