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Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice

机译:从Crassostrea hongkongensis生产免疫调节多糖及其作为调节5-FU化疗对小鼠有效性和毒性的营养因子的积极作用

摘要

Chemotherapy is generally accompanied by undesirable side effects, such as immunosuppression and malnutrition, which reduce tolerance to cancer therapies. Prior studies have shown that immunonutrition improves the clinical outcomes of cancer patients. In this study, immunoregulatory polysaccharides from Crassostrea hongkongensis were included in a nutrition formula that was administered to S180 tumor-bearing mice in combination with 5-fluorouracil (5-FU) treatment. The C30-60% fraction of the polysaccharides was characterized as a branched polysaccharide, with a high amount of D-glucose (96.76% of the total) and the highest uronic acid and sulfate groups' content among all of the polysaccharide fractions. The C30-60% polysaccharide fraction showed a maximal proliferative effect on RAW264.7 cells and T lymphocytes at a concentration of 0.0391 mg mL(-1) and 0.0781 mg mL-1, respectively. Moreover, the combination treatment of the C30-60% polysaccharide- based nutrition formula (OPNF) with the administration of 5-FU effectively inhibited the growth of tumors and notably increased the leucocyte and lymphocyte counts in S180 tumor-bearing mice. In addition, a slight increase in the erythrocyte and hemoglobin values was observed in the mice treated with the combination of OPNF and 5-FU. These results suggest that supplementation with a C30-60%-based enteral formula would be beneficial for patients undergoing chemotherapy with 5-FU.
机译:化学疗法通常伴随着不良的副作用,例如免疫抑制和营养不良,它们降低了对癌症疗法的耐受性。先前的研究表明,免疫营养可以改善癌症患者的临床结局。在这项研究中,来自香港景天属的免疫调节多糖被包括在营养配方中,该营养配方与5-氟尿嘧啶(5-FU)治疗联合施用于S180荷瘤小鼠。多糖的C30-60%馏分被表征为支链多糖,在所有多糖馏分中,D-葡萄糖含量高(占总量的96.76%),糖醛酸和硫酸盐基团的含量最高。 C30-60%多糖级分分别在0.0391 mg mL(-1)和0.0781 mg mL-1的浓度下对RAW264.7细胞和T淋巴细胞表现出最大的增殖作用。此外,将C30-60%多糖基营养配方食品(OPNF)与5-FU联合使用可有效抑制肿瘤生长,并显着增加S180荷瘤小鼠的白细胞和淋巴细胞计数。另外,在用OPNF和5-FU组合治疗的小鼠中观察到红细胞和血红蛋白值略有增加。这些结果表明,补充基于C30-60%的肠内配方对于接受5-FU化疗的患者将是有益的。

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