Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce

摘要

Two new prenylated phenols vaccinol H (1) and vaccinol I (2), together with three known phenols derivatives 3-5, one glyceride derivative 6, and ergosterol 7 were isolated from endogenous Pestalotiopsis vaccinii (cgmcc3.9199) of mangrove plant Kandelia candel (L.) Druce (Rhizophoraceae). The new structures of 1 and 2 were determined by spectroscopic analyses and circular dichroism (CD) spectra. Most of the isolated compounds (2-6) were tested for their antiviral (EV71), cytotoxic, anti-tuberculosis, and anti-inflammatory effects. Among these compounds, compound 2 exhibited potent COX-2 inhibitory activity with an IC50 value of 16.8 mM. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.