Spatiotemporal analysis of an agent-based model of a colony of keratinocytes: a first approach for the development of validation methods

摘要

Agent-based models are widely used for theudsimulation of systems from several domains (biology,udeconomics, meteorology, etc). In biology agent-basedudmodels are very useful for predicting the socialudbehaviour of systems; in particular they seem welludadapted to model the behaviour of a cell population.udIn this paper an agent-based model, developed toudstudy normal human keratinocytes (tissue cells), willudbe investigated. This kind of model exhibitsudprobabilistic behaviour and the validation ofudsimulation results is often done with a qualitativeudanalysis by the experts (biologists). The mainudobjective of this paper is to propose new variables andudmetrics that allow the comparison and a possibleudquantitative validation using numerical results fromudsimulations.