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Numerical simulation of in vivo indentation tests: determination of the mechanical properties of human skin

机译:体内压痕试验的数值模拟:人体皮肤力学性能的测定

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摘要

Human skin is the largest organ of the human body. It has a stratified structure consisting of four main layers: the stratum corneum, the viable epidermis, the dermis and the hypodermis. The skin protects the body against external influences when exposed to sun or to undesirable substances in case of pollution and to the direct application of external loads linked to clinical problems or aesthetic treatments. The state of this barrier (intact or damaged) governs its evolution and its answers. Studies of the mechanical behaviour of the human skin have shown that the human skin is a stratified non-homogeneous, anisotropic, non-linear-visco-elastic material which is subjected to a pre-stress in vivo. In addition its properties vary with age, throughout the body and per person. This paper proposes a bi-phasic model within the framework of a general phenomenological thermo-hydro-mechanical and physico-chemical approach of heterogeneous media which incorporates a solid phase with three solid materials (one for each outer layer of the skin) and a fluid phase. In order to write a closed mathematical problem, the field equations that arise from the model are complemented with initial and boundary conditions deduced from experimental tests performed in the laboratory on in vivo human skin on the indentation device developed by the LTDS. Numerical simulations of these indentation tests are proposed and allow the determination of the mechanical properties of the different layers of skin tissues in vivo.
机译:人体皮肤是人体最大的器官。它的分层结构由四个主要层组成:角质层,活表皮,真皮和皮下组织。当皮肤暴露在阳光下或受到污染时接触有害物质时,以及在与临床问题或美学治疗相关的外部负荷直接施加时,皮肤可以保护身体免受外部影响。此屏障的状态(完整或损坏)控制着它的演变及其答案。对人体皮肤的机械行为的研究表明,人体皮肤是分层的非均质,各向异性,非线性粘弹性材料,在体内受到预应力。此外,它的性质会随着年龄的变化,遍及整个身体和每个人。本文提出了一种多相介质的一般现象学热流体力学和物理化学方法框架内的双相模型,该方法将固相与三种固体材料(皮肤的每一外层都包含一种)结合在一起相。为了写一个封闭的数学问题,由模型产生的场方程与初始条件和边界条件相补充,初始条件和边界条件是由实验室在LTDS开发的压痕装置上对体内人体皮肤进行的实验测试得出的。提出了这些压痕测试的数值模拟,并允许确定体内皮肤组织不同层的机械性能。

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