Plasma-sprayed hydroxylapatite coatings on metallic prosthesis significantly increased the success rate of hip arthroplasty, namely from about 90% after 10 years for cemented hip stems to 98% for HA coated ones. Nowadays, the biomimetic approach has received increased interest because of the possible advantages of this route. The physiological conditions of the biomimetic process can broaden the variety of materials to be coated such as heatsensitive or porous implants, and the variety of calcium phosphate phases, including those that are solely stable under mild temperature conditions. In addition, drugs and growth factors can be easily included into such coatings. The aim of this thesis was to accelerate and to optimize the biomimetic process, to study the physicochemistry involved in the formation of calcium phosphate on a heterogeneous substrate, to evaluate the flexibility of the biomimetic route, and finally to investigate the in vitro and in vivo behavior ofthese novel coatings.
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