Fluorescence monitoring of capillary electrophoresis separation of biomolecules with monolithically integrated optical waveguides

摘要

Monolithic integration of optical waveguides in a commercial lab-on-a-chip by femtosecond-laser material processing enables arbitrary 3D geometries of optical sensing structures in combination with fluidic microchannels. Integrated fluorescence monitoring of molecular separation, as applicable in point-of-care diagnostic bioassays is demonstrated.