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Paramagnetic Complexes with Pendant Crown Compounds Showing Improved Targeting- Specificity as MRI Contrast Agents

机译：具有侧链冠状化合物的顺磁性复合物显示出改进的靶向特异性作为mRI造影剂

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Potential magnetic resonance imaging (MRI) contrast agents that are functionalized with crown compounds have been synthesized, and show target-specificity to the kidney and liver, along with excellent water solubility, high MR intensity enhancement efficiency, long resident lifetime, low dosage requirement, low cytotoxicity and prolonged excretion rate.

机译：已合成了用冠状化合物官能化的潜在磁共振成像（MRI）造影剂，这些造影剂对肾脏和肝脏具有靶标特异性，并具有出色的水溶性，高MR强度增强效率，长寿命，低剂量要求，细胞毒性低，排泄率高。

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1. Paramagnetic Cobalt(II) Complexes with Cyclam Derivatives: Toward F-19 MRI Contrast Agents [J] . Blahut Jan, Benda Ladislav, Kotek Jan, Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2020,第14期

机译：循环衍生物的顺磁钴（II）复合物：朝向F-19 MRI造影剂
2. Relative diffusion of paramagnetic metal complexes of MRI contrast agents in an isotropic hydrogel medium [J] . Bimali Sanjeevani Weerakoon, Toshiaki Osuga Radiological physics and technology . 2017,第1期

机译：在各向同性水凝胶培养基中MRI造影剂的副磁金属配合物的相对扩散
3. Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands - A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents [J] . Adam A.H. Elmehriki, Mark Milne, Mojmir Suchy Canadian Journal of Chemistry . 2013,第3期

机译：选定的晚期镧系元素（III）阳离子与1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸酰胺（DOTAM）-烷基配体的配合物-开发顺磁化学交换饱和的新平台转移（PARACEST）磁共振成像（MRI）造影剂
4. Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents [C] . Giancarlo Morelli, Antonella Accardo, Diego Tesauro International Peptide Symposium;European Peptide Symposium . 2005

机译：含有CCK8生物活性肽和GD复合物作为靶特异性MRI造影剂的多组分聚集体
5. Co(II), Fe(II), and Ni(II) Complexes for paraCEST Applications and a New Class of Fe(III) Macrocyclic Complexes as T1 MRI Contrast Agents [D] . Snyder, Eric M. 2020

机译：CO（II），Fe（II）和Ni（II）络合物用于Parast应用和新类Fe（III）宏环复合物作为T1 MRI造影剂
6. Improving T1 and T2 magnetic resonance imaging (MRI) contrast agents through the conjugation of an esteramide dendrimer to high water coordination Gd(III) hydroxypyridinone (HOPO) complexes [O] . Piper J. Klemm, William C. Floyd, Danil E. Smiles, -1

机译：通过将酯酰胺树枝状聚合物缀合至高水协调Gd（III）羟基吡啶酮（Hopo）络合物改善T1和T2磁共振成像（MRI）造影剂
7. Paramagnetic Lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications [O] . Silvio Aime, Alessandro Barge, Daniela Delli Castelli, 2002

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8. Poly (L-Glutamic Acid) Paramagnetic Material Complex and Use as a Biodegradable MRI Contrast Agent. [R] . Li, C., Wen, X., Jackson, E. F., 2004

机译：聚（L-谷氨酸）顺磁性材料复合物和用作可生物降解的mRI造影剂。

Paramagnetic Complexes with Pendant Crown Compounds Showing Improved Targeting- Specificity as MRI Contrast Agents

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