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Megahertz all-optical swept-source optical coherence tomography based on broadband amplified optical time-stretch

机译:基于宽带放大光学时间拉伸的兆赫全光扫描光学相干层析成像

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摘要

We demonstrate all-optical ultrahigh-speed swept-source optical coherence tomography (OCT) based on amplified optical time-stretch (AOT). Such an inertia-free wavelength-swept mechanism, via group velocity dispersion, enables us to realize OCT with an A-scan rate well above MHz. More importantly, the key significance of AOT-OCT is its simultaneous broadband Raman amplification during the time-stretch process-greatly enhancing the detection sensitivity compared with prior attempts to apply optical time-stretch to OCT. Here, we report on an AOT-OCT system which is operated at an A-scan rate of 7.14 MHz, a superior roll-off performance (>2 mm/dB), a record-high sensitivity of time-stretch-based OCT (>80 dB) with a broadband gain bandwidth of 80 nm, which results in an axial resolution of approximately 15 mum. Our AOT-OCT system is thus able to, for the first time to the best of our knowledge, perform time-stretch-based OCT of biological tissue in vivo. It represents a major step forward in utilizing AOT as an alternative for achieving practical MHz OCT, without any long-term mechanical stability concerns as in typical swept-source OCT or bypassing the speed limitation of the image sensor employed in spectral-domain OCT.
机译:我们演示了基于放大光学时间拉伸(AOT)的全光学超高速扫频源光学相干断层扫描(OCT)。这种无惯性的波长扫描机制,通过群速度色散,使我们能够以远高于MHz的A扫描速率实现OCT。更重要的是,AOT-OCT的关键意义在于它在时间拉伸过程中同时进行宽带拉曼放大,与先前将光学时间拉伸应用于OCT的尝试相比,极大地提高了检测灵敏度。在这里,我们报告了一种AOT-OCT系统,该系统以7.14 MHz的A扫描速率运行,具有出色的滚降性能(> 2 mm / dB),以及基于时间拉伸的OCT的创纪录的高灵敏度(大于80 dB)的宽带增益带宽为80 nm,这导致轴向分辨率约为15 mum。因此,据我们所知,我们的AOT-OCT系统首次能够在体内对生物组织进行基于时间拉伸的OCT。它代表了在利用AOT作为实现实际MHz OCT的替代方案方面迈出的重要一步,而无需像传统扫频OCT那样长期关注机械稳定性,也无需绕过光谱域OCT中使用的图像传感器的速度限制。

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