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Generating survival times to simulate Cox proportional hazards models

机译:生成生存时间以模拟Cox比例风险模型

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摘要

This paper discusses techniques to generate survival times for simulation studies regarding Cox proportional hazards models. In linear regression models, the response variable is directly connected with the considered covariates, the regression coefficients and the simulated random errors. Thus, the response variable can be generated from the regression function, once the regression coefficients and the error distribution are specified. However, in the Cox model, which is formulated via the hazard function, the effect of the covariates have to be translated from the hazards to the survival times, because the usual software packages for estimation of Cox models require the individual survival time data. A general formula describing the relation between the hazard and the corresponding survival time of the Cox model is derived. It is shown how the exponential, the Weibull and the Gompertz distribution can be used to generate appropriate survival times for simulation studies. Additionally, the general relation between hazard and survival time can be used to develop own distributions for special situations and to handle flexibly parameterized proportional hazards models. The use of other distributions than the exponential distribution only is indispensable to investigate the characteristics of the Cox proportional hazards model, especially in non-standard situations, where the partial likelihood depends on the baseline hazard.
机译:本文讨论了用于生成有关Cox比例风险模型的仿真研究的生存时间的技术。在线性回归模型中,响应变量与所考虑的协变量,回归系数和模拟的随机误差直接相关。因此,一旦指定了回归系数和误差分布,就可以从回归函数生成响应变量。但是,在通过危险函数表述的Cox模型中,必须将协变量的影响从危险转换为生存时间,因为估算Cox模型的常用软件包需要单独的生存时间数据。得出描述危险与Cox模型相应生存时间之间关系的一般公式。它显示了如何使用指数分布,威布尔分布和Gompertz分布来生成适当的生存时间以进行仿真研究。此外,危害与生存时间之间的一般关系可用于为特殊情况开发自己的分布并处理灵活的参数化比例危害模型。仅使用指数分布以外的其他分布来调查Cox比例风险模型的特征是必不可少的,尤其是在非标准情况下,其中部分可能性取决于基准风险。

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