Inflammatory cellular response and cytokines IL-1β, IL-6 and TNFα in rat and human spinal cord injury.

摘要

The goal of this study was to characterize the post-traumatic inflammatory responses and localize cellular sources of IL-1β, IL-6 and TNFα following SCI. Thus it was hypothesized that the pro-inflammatory cytokines IL-1β, IL-6 and TNFα may act as messengers to coordinate the inflammatory cascade in the secondary SCI and that the cytokine response should be greater in severe than in mild injury.