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Magnetophoretic circuits for digital control of single particles and cells.

机译:用于单个粒子和细胞的数字控制的磁泳电路。

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摘要

The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.
机译:借助现代计算机硬件的精确度和并行性,能够操纵小液滴,胶体颗粒和单细胞,这在生化检测,基因测序,化学合成和单细胞的高度并行分析中有着广泛的应用。从通用电路理论和磁泡技术中汲取灵感,在这里我们演示了一类用于在单个粒子和单元的集合中执行顺序和并行,定时操作的集成电路。集成电路由磁膜和电流线的光刻定义的重叠图案构成。磁性图案被动地控制类似于电导体,二极管和电容器的颗粒。电流线类似于门控电子晶体管,在不同的轨道之间主动切换粒子。当组合成阵列并由旋转磁场时钟驱动时,这些集成电路具有一般的多路复用特性,可以精确控制可磁化物体。

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