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Pyrimido4,5‐ d pyrimidin‐4(1 H )‐one Derivatives as Selective Inhibitors of EGFR Threonine 790 to Methionine 790 (T790M) Mutants

机译：嘧啶并4,5-d嘧啶-4（1H） - 酮衍生物作为EGFR苏氨酸790对甲硫氨酸790（T790m）突变体的选择性抑制剂

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Xu Tianfeng; Zhang Lianwen; Xu Shilin; Yang Chao‐yie; Luo Jinfeng; Ding Fang; Lu Xiaoyun; Liu Yingxue; Tu Zhengchao; Li Shiliang; Pei Duanqing; Cai Qian; Li Honglin; Ren Xiaomei; Wang Shaomeng; Ding Ke;
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1. Pyrimido[4,5-d]pyrimidin-4(lH)-one Derivatives as Selective Inhibitors of EGFR Threonine~(790) to Methionine~(790) (T790M) Mutants [J] . Tianfeng Xu, Lianwen Zhang, ShilinXu Angewandte Chemie . 2013,第32期

机译：Pyrimido [4,5-d] pyrimidin-4（lH）-one衍生物作为EGFR苏氨酸〜（790）对蛋氨酸〜（790）（T790M）突变体的选择性抑制剂
2. Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation [J] . Hao Yongjia, Lyu Jiankun, Qu Rong, Journal of Medicinal Chemistry . 2018,第13期

机译：嘧啶[4,5-D]嘧啶-2,4（1H，3H） - 作为有效的和选择性表皮生长因子受体（EGFR）抑制剂对L858R / T790M电阻突变的设计，合成和生物学评价
3. A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties [J] . Yu Lei, Huang Minhao, Xu Tianfeng, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2017,第期

机译：Pyrido [2,3-D]嘧啶-7-作为改善药代动力学性质的EGFR（L858R / T790M）突变体的选择性抑制剂的结构引导优化
4. Detection of EGFR T790M Mutation in Circulating Tumor DNA by Using a Novel Highly Sensitive PNA-Based Method [C] . Jin Kim, Ji-Youn Han, Geon Kook Lee, International Molecular Medicine Tri-Conference. . 2015

机译：用新型高敏感的基于PCNA的方法检测循环肿瘤DNA的EGFR T790M突变
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Structure-Guided Design of C4-alkyl-14-dihydro-2H-pyrimido45-d13oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors [O] . Yongjia Hao, Jiankun Lyu, Rong Qu, -1

机译：C4-烷基-14-二氢-2H-嘧啶45-d 13恶嗪-2-酮作为有效和突变体选择性表皮生长因子受体（EGFR）L858R /的结构指导设计T790M抑制剂
7. Pyrimido4,5‐ d pyrimidin‐4(1 H )‐one Derivatives as Selective Inhibitors of EGFR Threonine 790 to Methionine 790 (T790M) Mutants [O] . Xu Tianfeng, Zhang Lianwen, Xu Shilin, 2013

机译：嘧啶并4,5-d嘧啶-4（1H） - 酮衍生物作为EGFR苏氨酸790对甲硫氨酸790（T790m）突变体的选择性抑制剂

Pyrimido4,5‐ d pyrimidin‐4(1 H )‐one Derivatives as Selective Inhibitors of EGFR Threonine 790 to Methionine 790 (T790M) Mutants

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