Crystal structures of the HCl salts of pseudopeptidic macrocycles display ‘‘knobs into holes’’ hydrophobic interactions between aliphatic side chains

摘要

The crystal structures of three HCl salts of pseudopeptidic macrocycles show a H-bonding tubular stack of the rings, where the amino acidic side chains (Val, Leu, Ile) display an inter-columnar “knobs into holes” hydrophobic interaction pattern