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A fully automatic algorithm for assessing T2* and its certainty value for accurate cardiac and liver iron load determination

机译:一种全自动的评估T2 *的算法及其确定心脏和肝脏铁负荷确定的确定性值

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摘要

Quantification of myocardial and liver iron load has become a mainstay of guiding therapy in thalassaemia patients. However, current quantification methods are user dependent for data-point exclusion before curve fitting, and do not report the T2* certainty. Recently, an automatic inline maximum likelihood estimate (MLE) method with k-space Rician noise correction was validated against the reference standard manual truncation method. We now present a vendor-independent offline tool for fully automatic post processing and T2* quantification with certainty estimates, tested in computer simulations and patients with iron overload.
机译:地中海和肝脏铁负荷的量化已成为地中海贫血患者指导治疗的主要手段。但是,当前的量化方法取决于用户是否适合曲线拟合之前的数据点排除,并且没有报告T2 *确定性。最近,针对参考标准手动截断方法验证了具有k空间Rician噪声校正的自动在线最大似然估计(MLE)方法。现在,我们提供了独立于供应商的离线工具,用于全自动后处理和具有确定性估计的T2 *量化,并在计算机模拟和铁过载患者中进行了测试。

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