Medical differential diagnosis (ddx) is based on the estimation of multiple distinct parameters in order to determine the most probable diagnosis. Building an intelligent medical differential diagnosis system implies using a number of knowledge based technologies which avoid ambiguity, such as ontologies rep resenting specific structured information, but also strategies such as computation of probabilities of var ious factors and logical inference, whose combination outperforms similar approaches. This paper presents ODDIN, an ontology driven medical diagnosis system which applies the aforementioned strat egies. The architecture and proof of concept implementation is described, and results of the evaluation are discussed.
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