Antibacterial Activity of Alkaloid Extracts and Active Constituents of some Selected Plants against Xanthomonas campestris

摘要

The present investigation evaluates the antibacterial activity of alkaloid extracts of Acacia catechu, A. ferruginea, Adenanthera pavonina, Albizia amara, A. saman, Breynia vitis-idaea, Senna spectabilis and Solanum indicum, and bioactive compounds budmunchiamine-A isolated from A. amara and pithecolobine from A. saman against an important phytopathogen Xanthomonas campestris. The results revealed that alkaloid extracts of all plants showed significant antibacterial activity with zone of inhibition (ZOI), minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) ranged from 9.1 to 12.5 mm, 31.25 to 500 µg/ml and 125 to 2000 µg/ml, respectively. The active compounds isolated from alkaloid extract of A. amara and A. saman have been identified as budmunchiamine-A and pithecolobine, respectively. The active compounds budmunchiamine-A and pithecolobine showed concentration-dependent anti-X. campestris activity with ZOI, MIC and MBC ranged from 12.6 to 20.3 mm, 15.6 to 31.2 µg/ml and 62.5 to 125 µg/ml, respectively. The results revealed that alkaloid extracts of these plants as well as budmunchiamine-A and pithecolobine could be used as an alternative strategy for the management of diseases caused by Xanthomonas spp.