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Solid lipid particles for improved dermal delivery of virgin coconut oil

机译:固体脂质颗粒可改善原始椰子油的真皮输送

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摘要

Coconut oil has been recognized as a health oil in Ayurverdic medicine. Virgin Coconut Oil (VCO) is unique because it has a high degree of saturated fats, medium chain triglycerides, antioxidant activity and antimicrobials property. These factors make VCO a suitable lipophilic active ingredient in skin care products. VCO is usually extracted from well matured and fresh coconut through specialized process and is prepared in such a way that does not damage its natural structure or nutrition. Solid Lipid Particles (SLPs) is a novel delivery system of lipophilic functional cosmetic active ingredients. In this work, formulation, characterization and efficacy of VCO-SLPs have been studied. VCO-SLPs were prepared using ultrasonification of molten stearic acid and virgin coconut oil in an aqueous solution. From screening experiments, the best formula for VCO-SLPs was 1.78% Tween 80, 0.73% soy lecithin, 10% stearic acid, 5% VCO and 82.5% distilled water. Ultrasonicating was performed at several power intensities and different exposure times. The particle sizes of VCO-SLPs obtained were ranged from 0.608 µm to 44.265 µm. The zeta potentials of all the particles were from -43.2 mV to -47.5 mV showing that the particles obtained have good stability. The cumulative permeation of the VCO-SLPs range from 3.83 µg/cm2 to 3.59 µg/cm2 for VCO-SLPs in the range of 0.608 µm to 39.255 µm. VCO-SLPs with the particle size of 0.608 µm was chosen for subsequent study. Double blind skin evaluation test was conducted to analyze the performance of the VCO-SLPs incorporated moisturizing lotion. Moisturizing lotion incorporated with VCO-SLPs was found to increase skin hydration and skin elasticity by 24.8% and 2.60% respectively from day 0 to day 28. This shows that solid lipid particles has the potential to be utilized as a carrier for improved dermal delivery of VCO.
机译:椰子油已被认为是印度草药中的健康油。初榨椰子油(VCO)独特,因为它具有高度的饱和脂肪,中链甘油三酸酯,抗氧化活性和抗菌性能。这些因素使VCO成为护肤产品中合适的亲脂性活性成分。 VCO通常是通过特殊工艺从成熟度高的新鲜椰子中提取的,其制备方式不会损害其天然结构或营养。固体脂质颗粒(SLP)是亲脂功能性化妆品活性成分的新型递送系统。在这项工作中,已经研究了VCO-SLP的配方,特性和功效。使用熔融的硬脂酸和纯椰子油在水溶液中的超声处理来制备VCO-SLP。通过筛选实验,VCO-SLP的最佳配方为1.78%吐温80、0.73%大豆卵磷脂,10%硬脂酸,5%VCO和82.5%蒸馏水。在几种功率强度和不同的曝光时间下进行超声处理。所获得的VCO-SLP的粒径为0.608μm至44.265μm。所有颗粒的ζ电势为-43.2mV至-47.5mV,表明获得的颗粒具有良好的稳定性。对于VCO-SLP,VCO-SLP的累积渗透率为3.83 µg / cm2至3.59 µg / cm2,范围为0.608 µm至39.255 µm。选择了粒径为0.608 µm的VCO-SLP进行后续研究。进行了双盲皮肤评估测试,以分析掺入保湿乳液的VCO-SLP的性能。发现与VCO-SLP结合的保湿乳液从第0天到第28天分别增加了皮肤水合作用和皮肤弹性,分别提高了24.8%和2.60%。这表明,固体脂质颗粒有可能被用作改善皮肤的真皮递送的载体。 VCO。

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  • 作者

    Mohamed Noor Norhayati;

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  • 年度 2013
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  • 正文语种 en
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