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Fully 2’-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA

机译：与未修饰的小干扰RNa相比，完全2'-修饰的寡核苷酸双链体具有改善的体外效力和稳定性

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Charles R. Allerson; Namir Sioufi; Russell Jarres; Thazha P. Prakash; Nishant Naik; Andres Berdeja; Lisa W; Richard H. Griffey; Eric E. Swayze; Balkrishen Bhat;
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年度 2005
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1. Fully 2'-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA [J] . Charles R.Allerson, Namir Sioufi, Russell Jarres, Journal of Medicinal Chemistry . 2005 ,第4期

机译：与未修饰的小干扰RNA相比，具有增强的体外效能和稳定性的完全2'-修饰的寡核苷酸双链体
2. Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 30-Exonuclease Stability Compared to That of the LNA Modified or theNativeCounterparts:AMichaelis-Menten KineticAnalysis [J] . Chuanzheng Zhou, Jyoti Chattopadhyaya The Journal of Organic Chemistry . 2010 ,第7期

机译：为什么Carba-LNA修饰的寡核苷酸与LNA修饰的或天然对等物相比显示出显着改善的30-核酸外切酶稳定性：A Michaelis-Menten动力学分析
3. Improving RNA Interference in Mammalian Cells by 4'-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2'-O-Alkyl Modifications [J] . Prasad Dande, Thazha P.Prakash, Namir Sioufi, Journal of Medicinal Chemistry . 2006 ,第5期

机译：通过4'-硫代修饰的小分子干扰RNA（siRNA）改善哺乳动物细胞中的RNA干扰：与2'-O-烷基修饰结合使用时，对siRNA活性和核酸酶稳定性的影响
4. Molecular dynamics simulation of immobilized oligonucleotides hybrid duplexes modified with different length of poly-thymidine spacer molecules [C] . Zunliang Wang, Nongyue He, Zhiyang Li International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：不同长度的聚胸苷间隔分子修饰的固定化寡核苷酸杂交双链体的分子动力学模拟
5. Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors [D] . Waite, Carolyn Leigh 2011

机译：工程化靶向肿瘤的聚（酰胺基胺）（PAMAM）树状大分子，以提高短干扰RNA（siRNA）通过实体瘤的渗透和细胞递送
6. Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes [O] . Damian Ittig, Anna-Barbara Gerber, Christian J. Leumann 2011

机译：位置依赖性对三环DNA修饰的寡核苷酸双链体稳定性的影响
7. Fully 2-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA [O] . -1

机译：与未修饰的小干扰RNA相比，完全2-修饰的寡核苷酸双链体具有改善的体外效力和稳定性

Fully 2’-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA

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