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Improving RNA Interference in Mammalian Cells by 4′-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2′-O-Alkyl Modifications

机译：通过4'-硫代修饰的小干扰RNa（siRNa）改善哺乳动物细胞中的RNa干扰：当与2'-O-烷基修饰组合使用时对siRNa活性和核酸酶稳定性的影响

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Prasad D; Thazha P. Prakash; Namir Sioufi; Hans Gaus; Russell Jarres; Andreas Berdeja; Eric E. Swayze; Richard H. Griffey; Balkrishen Bhat;
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年度 2005
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1. Improving RNA Interference in Mammalian Cells by 4'-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2'-O-Alkyl Modifications [J] . Prasad Dande, Thazha P.Prakash, Namir Sioufi, Journal of Medicinal Chemistry . 2006,第5期

机译：通过4'-硫代修饰的小分子干扰RNA（siRNA）改善哺乳动物细胞中的RNA干扰：与2'-O-烷基修饰结合使用时，对siRNA活性和核酸酶稳定性的影响
2. Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications. [J] . Dande P, Prakash TP, Sioufi N, Journal of Medicinal Chemistry . 2006,第5610期

机译：通过4'-硫基修饰的小分子干扰RNA（siRNA）改善哺乳动物细胞中的RNA干扰：与2'-O-烷基修饰结合使用时，对siRNA活性和核酸酶稳定性有影响。
3. Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3 '-ends of siRNAs [J] . Hamada M, Ohtsuka T, Kawaida R, Antisense & Nucleic Acid Drug Development . 2002,第5期

机译：错配的哺乳动物细胞对基因表达（RNAi）中RNA干扰的影响以及在siRNA 3'末端引入化学修饰
4. Filtering of ineffective siRNAs and improved siRNA design tool [C] . Prudence W. H. Wong, T. W. Lam, Y. C. Mui, Proceedings of the Second conference on Asia-Pacific bioinformatics . 2004

机译：过滤无效的siRNA和改进的siRNA设计工具
5. Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors [D] . Waite, Carolyn Leigh 2011

机译：工程化靶向肿瘤的聚（酰胺基胺）（PAMAM）树状大分子，以提高短干扰RNA（siRNA）通过实体瘤的渗透和细胞递送
6. Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance thermal stability and RNAi activity [O] . Joel M Harp, Dale C Guenther, Anna Bisbe, 2018

机译：siRNA核酸酶抗性热稳定性和RNAi活性的4和2修饰协同作用的结构基础
7. Improving RNA Interference in Mammalian Cells by 4-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2-O-Alkyl Modifications [O] . -1

机译：通过4-硫代改性的小干扰RNA（siRNA）改善哺乳动物细胞的RNA干扰：与2-O-烷基修饰组合使用时对siRNA活性和核酸酶稳定性的影响

Improving RNA Interference in Mammalian Cells by 4′-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2′-O-Alkyl Modifications

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