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The HLA–DRB1 Shared Epitope Alleles Are Primarily a Risk Factor for Anti–Cyclic Citrullinated Peptide Antibodies and Are Not an Independent Risk Factor for Development of Rheumatoid Arthritis

机译：HLA–DRB1共有的表位等位基因主要是抗环瓜氨酸肽抗体的危险因素，而不是类风湿关节炎发展的独立危险因素

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Kirsten N. Verpoort; C. Breedveld; Tom W. J. Huizinga; René E. M. Toes; René R. P. De Vries;
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1. Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA–DRB1 shared epitope, regardless of rheumatoid factor or anti–cyclic citrullinated peptide antibody status [J] . So-Young Bang, Kyoung-Ho Lee, Soo-Kyung Cho, Arthritis & Rheumatism . 2010,第2期

机译：吸烟会增加携带HLA–DRB1共有表位的类风湿关节炎的易感性，无论类风湿因子或抗环瓜氨酸肽抗体状态如何
2. The significance of antibodies to cyclic citrullinated peptide, antikeratin antibodies, anti-perinuclear factor, rheumatoid factor isotypes and HLA shared epitope in prediction of erosive disease in early rheumatoid arthritis patients [J] . J Vencovsky, L Sedova, S Machacek, Arthritis Research . 2001,第SupplaA期

机译：抗环瓜氨酸肽，抗角蛋白抗体，抗核蛋白，类风湿因子同型和HLA共有表位的抗体在预测类风湿关节炎早期糜烂性疾病中的意义
3. Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status [J] . BangS.-Y., LeeK.-H., ChoS.-K., Arthritis and Rheumatism . 2010,第2期

机译：吸烟会增加携带HLA-DRB1共有表位的个体的类风湿关节炎易感性，无论类风湿因子或抗环瓜氨酸肽抗体状态如何
4. Lack of response to classic treatment is associated with anti-cyclic citrullinated peptide antibodies but not with drb1-se status in patients with recent-onset rheumatoid arthritis [C] . Manzanares B., Martinez F., Gonzalez R., European Congress of Immunology . 2009

机译：缺乏对经典治疗的反应与抗循环瓜氨酸肽抗体有关，但近期发病类风湿性关节炎的患者没有使用DRB1-SE状态
5. The novel use of recombinant granulocyte-macrophage colony stimulating factor (GM-CSF) to reverse cerebral amyloidosis and cognitive impairment in Alzheimer's disease mouse models: Insights from the investigation of Rheumatoid arthritis as a negative risk factor for Alzheimer's disease [D] . Boyd, Timothy David 2010

机译：重组粒细胞巨噬细胞集落刺激因子（GM-CSF）在阿尔茨海默氏病小鼠模型中逆转脑淀粉样变性和认知障碍的新用途：类风湿关节炎作为阿尔茨海默氏病的阴性危险因素研究的启示
6. Association of Valine and Leucine at HLA–DRB1 Position 11 With Radiographic Progression in Rheumatoid Arthritis Independent of the Shared Epitope Alleles but Not Independent of Anti–Citrullinated Protein Antibodies [O] . H. W. van Steenbergen, S. Raychaudhuri, L. Rodríguez-Rodríguez, -1

机译：HLA–DRB1位点上的缬氨酸和亮氨酸与类风湿关节炎的放射学进展的相关性独立于共有的表位等位基因但不独立于抗瓜氨酸化蛋白抗体
7. Smoking is a risk factor for anti‐CCP antibodies only in rheumatoid arthritis patients who carry HLA‐DRB1 shared epitope alleles [O] . Linn‐Rasker, S P, van der Helm‐van Mil, A H M, van Gaalen, F A, 2006

机译：仅在携带HLA‐DRB1共享表位等位基因的类风湿关节炎患者中吸烟是抗CCP抗体的危险因素

The HLA–DRB1 Shared Epitope Alleles Are Primarily a Risk Factor for Anti–Cyclic Citrullinated Peptide Antibodies and Are Not an Independent Risk Factor for Development of Rheumatoid Arthritis

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