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Improved Production and Purification of Minicircle DNA Vector Free of Plasmid Bacterial Sequences and Capable of Persistent Transgene Expression In Vivo

机译：改进的生产和纯化无质粒细菌序列的小圆环DNA载体，并能够在体内持久表达基因

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Mary Ann Liebert; Zhi-ying Chen; Cheng-yi He; Mark A. Kay;
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年度 2014
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1. Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. [J] . Chen ZY, He CY, Ehrhardt A, Molecular therapy: the journal of the American Society of Gene Therapy . 2003,第3期

机译：不含细菌DNA的小环DNA载体可在体内持续和高水平表达转基因。
2. Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo. [J] . Chen ZY, He CY, Meuse L, Gene therapy . 2004,第10期

机译：在体内通过质粒细菌DNA元件沉默游离型转基因表达。
3. Critical design criteria for minimal antibiotic-free plasmid vectors necessary to combine robust RNA Pol II and Pol III-mediated eukaryotic expression with high bacterial production yields [J] . Carnes A.E., Luke J.M., Vincent J.M., The journal of gene medicine . 2010,第10期

机译：关键的设计标准，要求将强大的RNA Pol II和Pol III介导的真核表达与高细菌产量结合起来所需的最少无抗生素质粒载体
4. Escherichia coli Plasmid DNA Fermentation: Strain and Process-Specific Effects on Vector Yield, Quality and Transgene Expression [C] . Aaron E. Cannes, Jeremy Luke, Justin M. Vincent, Vaccine Technology Symposium . 2010

机译：大肠杆菌质粒DNA发酵：菌株和工艺特异性对载体产率，质量和转基因表达的影响
5. Rapid Cell Free Synthesis of Minicircle Plasmid DNA for Gene Therapy. [D] . Tucker, Matthew Wyatt. 2017

机译：用于基因治疗的小环质粒DNA的快速无细胞合成。
6. Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid DNA vectors in a mouse model of acute lung injury [O] . Maria Florian, Jia-Pey Wang, Yupu Deng, 2021

机译：基因工程化间充质干细胞：在急性肺损伤小鼠模型中具有更高的转基因表达和疗效与细胞瘤中的疗效。
7. 292. Mini-Intronic Plasmid (MIP) Vector Sequences Enhance AAV-Mediated Transgene Expression In Vitro and In Vivo [O] . 2014

机译：迷你内肾上腺素（MIP）载体序列在体外和体内增强AAV介导的转基因表达

Improved Production and Purification of Minicircle DNA Vector Free of Plasmid Bacterial Sequences and Capable of Persistent Transgene Expression In Vivo

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