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>A mild and efficient palladium-catalyzed cyanation of aryl chlorides with K4Fe(CN)6
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A mild and efficient palladium-catalyzed cyanation of aryl chlorides with K4Fe(CN)6
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机译:K4 Fe(CN)6温和有效地钯催化芳基氯化物的氰化
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摘要
An efficient palladium-catalyzed cyanation of aryl chlorides is established. In the presence of a highly effective Pd/CM-phos catalyst, cyanation of aryl chlorides proceeds at 70 °C in general, which is the mildest reaction temperature achieved so far for this process. Common functional groups such as keto, aldehyde, ester, nitrile and-NH2, and heterocyclic coupling partners including N-H indoles are well tolerated. Moreover, a sterically hindered nonactivated ortho,ortho-disubstituted electrophile is shown to be a feasible coupling partner in cyanation.
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