Catalytic asymmetric addition of alkynylzinc reagents to ketones using polymer-supported chiral Schiff-base amino alcohols

摘要

Polymer-supported Schiff-base of optically active amino alcohols was used as chiral ligands in the enantioselective addition of alkynylzinc to simple ketones. At a 10 mol % ligand loading, chiral propargylic alcohols with moderate to good ee values (up to 89%) were produced. The polymeric catalyst could be recycled many times and used for further reactions.