首页> 外文OA文献 >Synthesis and cytotoxicity study of alkannin derivatives
【2h】

Synthesis and cytotoxicity study of alkannin derivatives

机译:链烷烃衍生物的合成及细胞毒性研究

摘要

Alkannin derivatives (3-19) were prepared through the reaction of β,β-dimethylacrylalkannin (1), the most abundant isohexenylnaphthazarin isolated from the roots of Arnebia euchroma, with different types of nucleophiles such as amines and thiols in the absence or presence of a reducing agent. The cytotoxicities of 1-8, 10-14 and 19 against four human carcinoma cell line (GLC-82, CNE2, Bel-7402, K-562) were found to be markedly higher than that of the naturally occurring β,β- dimethylacrylalkannin (1) and acetylalkannin (2). This study also shed light on the understanding of the biological activities in terms of the chemical reactivity of alkannins.
机译:Alkannin衍生物(3-19)是通过β,β-二甲基丙烯链烷酮(1)与不同类型的亲核试剂(如胺和硫醇)在不存在或存在下的反应而制得的。还原剂。发现1-8、10-14和19对四种人类癌细胞系(GLC-82,CNE2,Bel-7402,K-562)的细胞毒性明显高于天然存在的β,β-二甲基丙烯酸链烷烃(1)和乙酰链烷烃(2)。这项研究还从链烷素的化学反应性上阐明了对生物活性的理解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号