Ligand-controlled enantioselective 2+2 cycloaddition of oxabicyclic alkenes with terminal alkynes using chiral iridium catalysts

摘要

The first catalytic asymmetric [2 + 2] cycloaddition of oxabicyclic alkenes and terminal alkynes has been developed. This iridium-catalyzed enantioselective [2 + 2] cycloaddition allows the formation of four stereocenters in a single step with excellent enantioselectivity (94-99% ee).