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Effect of Tacrine-3-caffeic Acid, a novel multifunctional anti-Alzheimer's Dimer, against oxidative-stress-induced cell death in HT22 Hippocampal Neurons : involvement of Nrf2/HO-1 pathway

机译：Tacrine-3-caffeic acid，一种新型的多功能抗阿尔茨海默病二聚体，抗氧化应激诱导的HT22海马神经元细胞死亡：Nrf2 / HO-1途径的参与

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Aims: Oxidative stress (OS) plays an important role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). This study was designed to uncover the cellular and biochemical mechanisms underlying the neuroprotective effects of tacrine3-caffeic acid (T3CA), a novel promising multifunctional anti-Alzheimer's dimer, against OS-induced neuronal death.

机译：目的：氧化应激（OS）在神经退行性疾病（包括阿尔茨海默氏病（AD））的发病机理中起重要作用。这项研究的目的是揭示潜在的塔克林3-咖啡酸（T3CA）的神经保护作用的细胞和生化机制。塔克林3-咖啡酸是一种新型有希望的多功能抗阿尔茨海默氏二聚体，可抵抗OS诱导的神经元死亡。

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Chao, XJ; Chen, ZW; Liu, AM; He, XX; Wang, SG; Wang, YT; Liu, PQ; Ramassamy, C; Mak, SH; Cui, W; Kong, AN; Yu, ZL; Han, YF; Pi, RB;
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1. Effect of tacrine-3-caffeic acid, a novel multifunctional anti-alzheimer's dimer, against oxidative-stress-induced cell death in HT22 hippocampal neurons: Involvement of Nrf2/HO-1 pathway [J] . ChaoX.-J., ChenZ.-W., LiuA.-M., CNS neuroscience & therapeutics . 2014,第9期

机译：Tacrine-3-caffeic acid，一种新型的多功能抗阿兹海默氏二聚体，抗氧化应激诱导的海马HT22海马神经元细胞死亡的作用：Nrf2 / HO-1通路的参与
2. Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells [J] . HuangW.-Y., ChaoX.-J., OuyangY., CNS neuroscience & therapeutics . 2012,第11期

机译：Tacrine-6-Ferulic Acid，一种新型的针对阿尔茨海默氏病的多功能二聚体，通过激活HT22细胞中的Nrf2 / ARE / HO-1途径，预防氧化应激诱导的神经元死亡。
3. Effect of Tacrine‐3‐caffeic Acid, A Novel Multifunctional Anti‐Alzheimer's Dimer, Against Oxidative‐Stress‐Induced Cell Death in HT 22 Hippocampal Neurons: Involvement of Nrf2/ HO ‐1 Pathway [J] . Xiao‐Juan Chao, Zi‐Wei Chen, An‐Min Liu, CNS neuroscience & therapeutics. . 2014,第9期

机译：Tacrine-3咖啡因酸，一种新型的多功能抗阿尔茨海默氏二聚体，对HT 22海马神经元氧化应激诱导的细胞死亡的影响：Nrf2 / HO -1途径的参与。
4. Uric acid prevents traumatic cell death and neuronal dysfunction in organotypic hippocampal slice cultures [C] . Goletiani C., Morrison B. IEEE Annual Northeast Bioengineering Conference . 2010

机译：尿酸预防器官型海马切片培养中的创伤性细胞死亡和神经元功能障碍
5. Anti-cancer Activities of Ursolic Acid in Human Breast Cancer Cells through Nrf2 Pathway Regulation [D] . Zhang, Xi. 2018

机译：通过NRF2途径调节尿酸尿酸中熊酸的抗癌活性
6. Effect of Tacrine‐3‐caffeic Acid A Novel Multifunctional Anti‐Alzheimers Dimer Against Oxidative‐Stress‐Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO‐1 Pathway [O] . Xiao‐Juan Chao, Zi‐Wei Chen, An‐Min Liu, 2014

机译：新型多功能抗阿尔茨海默氏二聚体Tacrine-3咖啡因对HT22海马神经元氧化应激诱导的细胞死亡的影响：Nrf2 / HO-1途径的参与。
7. Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-induced cell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway. [O] . Chao, Xiao-Juan, Chen, Zi-Wei, Liu, An-Min, 2014

机译：Tacrine-3-caffeic acid，一种新型的多功能抗阿尔茨海默氏症二聚体，抗氧化应激诱导的HT22海马神经元细胞死亡的作用：Nrf2 / HO-1途径的参与。

Effect of Tacrine-3-caffeic Acid, a novel multifunctional anti-Alzheimer's Dimer, against oxidative-stress-induced cell death in HT22 Hippocampal Neurons : involvement of Nrf2/HO-1 pathway

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