Facile preparation of chiral 1,3-diols via stereoselective transfer hydrogenation of 1,3-diones

摘要

Asymmetric reduction of 1,3-diones catalyzed by (S,S)-TsD-PEN-Ru (II) complex in a mixture of formic acid-triethylamine proceeded with a substrate/catalyst molar ratio of 100 to give (S, S)-1,3-diols with excellent diastereomeric (98.6% de) and enantiomeric purities (> 99% ce). Other C-2-symmetric diols were also obtained in almost quantitative yields with high diastereomeric (80.0%-84.2% de) and enantiomeric purities(> 99% ee).