The synthesis of new chiral phosphine-phosphinites, phosphine- phosphoramidite, and phosphine-phosphite ligands and their applications in asymmetric hydrogenation

摘要

New chiral phosphine-phosphinite, phosphine-phosphoramidite ligands and phosphine-phosphite 1a, 1b, 2 and 3 have been synthesized and examined in the enantioselective hydrogenation of dehydroamino acid derivatives and α-aryl enamides. The results demonstrate that both rhodium-1b and rhodium-2 complexes were highly efficient catalysts in asymmetric hydrogenation reactions (up to 99.6% ee was obtained).