Electrospun polymeric dressings functionalized with antimicrobial peptides and collagen type I for enhanced wound healing

摘要

Modern wound dressings combine medical textiles with active compounds thatstimulate wound healing while protecting against infection. Electrospun wound dressings havebeen extensively studied and the electrospinning technique recognized as an efficient approachfor the production of nanoscale fibrous mats. The unique diverse function and architecture ofantimicrobial peptides (AMPs) has attracted considerable attention as a tool for the design ofnew anti-infective drugs. Functionalizing electrospun wound dressings with these AMPs isnowadays being researched. In the present work, we explore these new systems by highlightingthe most important characteristics of electropsun wound dressings, revealing the importance ofAMPs to wound healing, and the methods available to functionalize the electrospun mats withthese molecules. The combined therapeutic potential of collagen type I and these AMPfunctionalized dressings will be highlighted as well; the significance of these new strategies forthe future of wound healing will be clarified.