Electrospun fibres of an elastin-like polymer functionalized with an antimicrobial domain

摘要

This work describes the production and characterization of nanofibres of a functionalized elastin-like recombinamer (ELR). The polymer was functionalized with an antimicrobial peptide domain by means of recombinant DNA technology and processed by electrospinning. The electrospun fibres were characterized for their morphology, physical-chemical, antimicrobial and cytotoxicity properties. The electrospun membranes showed no cytotoxicity against skin-related cell lines, suggesting the potential applicability of these materials for skin tissue engineering.