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Bioactive nanocomposite spheres with proved shape memory capability in bone defects

机译:具有骨形状缺陷记忆功能的生物活性纳米复合球

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摘要

Bioactive glass nanoparticles (BGNPs) promote an apatite surface layer in physiologic conditions that lead to a good interfacial bonding with bone.1 A strategy to induce bioactivity in non-bioactive polymeric biomaterials is to incorporate BGNPs in the polymer matrix. This combination creates a nanocomposite material with increased osteoconductive properties. Chitosan (CHT) is a polymer obtained by deacetylation of chitin and is biodegradable, non-toxic and biocompatible. The combination of CHT and the BGNPs aims at designing biocompatible spheres promoting the formation of a calcium phosphate layer at the nanocomposite surface, thus enhancing the osteoconductivity behaviour of the biomaterial. Shape memory polymers (SMP) are stimuli-responsive materials that offer mechanical and geometrical action triggered by an external stimulus.2 They can be deformed and fixed into a temporary shape which remains stable unless exposed to a proper stimulus that triggers recovery of their original shape. This advanced functionality makes such SMPs suitable to be implanted using minimally invasive surgery procedures. Regarding that, the inclusion of therapeutic molecules becomes attractive.  We propose the synthesis of shape memory bioactive nanocomposite spheres with drug release capability.3 1.  L. L. Hench, Am. Ceram. Soc. Bull., 1993, 72, 93-98.2.  A. Lendlein and S. Kelch, Angew Chem Int Edit, 2002, 41, 2034-2057.3.  Ã . J. Leite, S. G. Caridade and J. F. Mano, Journal of Non-Crystalline Solids (in Press)
机译:生物活性玻璃纳米颗粒(BGNP)在生理条件下促进磷灰石表面层,从而导致与骨骼的良好界面结合。1在非生物活性聚合物生物材料中诱导生物活性的策略是将BGNPs引入聚合物基质中。这种结合产生了具有增强的骨传导性能的纳米复合材料。壳聚糖(CHT)是通过几丁质脱乙酰化获得的聚合物,可生物降解,无毒且具有生物相容性。 CHT和BGNP的组合旨在设计生物相容性球体,从而促进在纳米复合材料表面形成磷酸钙层,从而增强生物材料的骨传导性。形状记忆聚合物(SMP)是刺激响应性材料,可提供由外部刺激触发的机械和几何作用。2它们可以变形并固定为临时形状,除非受到适当的刺激以触发其原始形状的恢复,否则该形状将保持稳定。 。这种先进的功能使此类SMP适合使用微创手术程序植入。关于这一点,包含治疗分子变得有吸引力。我们提出了具有药物释放能力的形状记忆生物活性纳米复合球的合成方法.3 1. L. L. Hench,Am。陶瓷Soc。 Bull,1993,72,93-98.2。 A.Lenddlein和S.Kelch,Angew Chem Int Edit,2002,41,2034-2057.3。一个 。 J. Leite,S。G. Caridade和J. F. Mano,《非晶体固体杂志》(印刷中)

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