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Timing embryo segmentation : dynamics and regulatory mechanisms of the vertebrate segmentation clock

机译:定时胚胎分割:脊椎动物分割时钟的动力学和调控机制

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摘要

All vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating geneticnetwork, the somitogenesis molecular clock. Herein, we provide an overview of the molecular clock operating during somite formation and its underlying molecular regulatory mechanisms. Human congenital vertebral malformations have been associatedwith perturbations in these oscillatory mechanisms. Thus, a better comprehension of the molecular mechanisms regulating somite formation is required in order to fully understand the origin of human skeletal malformations.
机译:所有脊椎动物物种都有一个分段的身体,很容易在脊椎动物柱及其相关组件中观察到,这为成年动物提供了高度的运动能力,并有效保护了其内部器官。胚胎发育过程中椎骨节段前体的顺序形成是由一个振荡的遗传网络即体发生分子钟控制的。在本文中,我们提供了对在somite形成过程中运行的分子钟及其潜在分子调控机制的概述。人类先天性脊椎畸形已与这些振荡机制中的摄动相关联。因此,为了更好地理解人类骨骼畸形的起源,需要更好地理解调节体节形成的分子机制。

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