Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection

摘要

The detection of cancer at its earliest stage is crucial in order to increase theprobability of a successful treatment. Optical techniques, specifically diffuse reflectance andfluorescence, may considerably improve the ability to detect pre-cancerous lesions. Thesetechniques have high sensitivity to some biomarkers present on the tissues, providingmorphological and biochemical information of normal and diseased tissue. Thedevelopment of a chip sized spectroscopy microsystem, based on these techniques, willgreatly improve the early diagnosis of gastrointestinal cancers. The main innovation is thedetection of the spectroscopic signals using only few, but representative, spectral bandsallowing for miniaturization. This paper presents the mathematical models, its validation andanalysis for retrieving data of the measured spectroscopic signals. These models were appliedto a set of phantoms clearly representative of gastrointestinal tissues, leading to a more accuratediagnostic by a pathologist. Moreover, it was demonstrated that the models can use thereconstructed spectroscopic signals based only on its extraction on those specific spectralbands. As a result, the viability of the spectroscopy microsystem implementation was proved.