Development of a bilayered scaffold based on silk fibroin and silk fibroin/nano-calcium phosphate for osteochondral regeneration

摘要

Objectives: Osteochondral defect is a common condtion in clinic. Satisfactoryoutcomes are rarely achieved by traditional methods. Tissueengineering might be a promising strategy for this hinder. The aim ofthis study is to mimick the stratified structure of osteochondral tissue,by developing a bilayered scaffold for osteochondral regeneration. Thedeveloped bilayered scaffold is composed of a porous silk fibroin scaffoldas the cartilage-like layer and a porous silk fibroin/nano-calciumphosphate (CaP) scaffold as the bone-like layer.