Synthesis and biological activity of some pyrimidine derivatives.

摘要

To synthesize a variety of pyrimidine analogs, 3, 4, 5, 6(a–d), 7(a–d) and their anticonvulsant and antioxidant activity was determined.udMethods Using 5-bromo-2,4-dichloropyrimidine and hydrazine hydrate, new compounds were synthesized. The structures of all the new compounds are established on the basis of FT-IR, 1H NMR and mass spectral data. Anticonvulsant study was done by MES seizure model and rotorod method was employed to determine the neurotoxicity. Antioxidant activity was done by DPPH method.udResults All the compounds were synthesized in good yield. Among the new compounds, 6c and 7c are found to be most potent and showed no neurotoxicity. All the compounds showed DPPH radical scavenging activity, where compounds 7b, 7a and 6b were the best radical scavengers.