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Spectrophotometric determination of zolmitriptan in bulk drug and pharmaceuticals using vanillin as a reagent.

机译:使用香兰素为试剂分光光度法测定散装药物和药品中的佐米曲普坦。

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摘要

An accurate and precise spectrophotometric method is presented for the detn. of zolmitriptan (ZMT) based on the formation of a red color product with vanillin in presence of concd. H2SO4, with the chromogen being measured at 580 nm. The reaction proceeds quant. at room temp. in 10 min. The calibration curve is linear over the range 5.0-90.0 μgmL-1 and described by the regression equation Y = (-)0.0101 + 0.0117X with a regression coeff. (r) of 0.9994 (n = 7). The calcd. molar absorptivity and Sandell sensitivity values are 3.3 × 103 Lmol-1cm-1 and 0.0872 μgcm-2, resp. The limits of detection (LOD) and quantification (LOQ) calcd. as per ICH guidelines are 1.26 and 3.81 μgmL-1, resp. The within-day accuracy expressed as relative error was better than 1.78% with precision (RSD) ranging from 0.83 to 1.45 %. The between-day accuracy ranged from 1.21 to 1.84 % with a precision less than 1.66%. The method was successfully applied to the anal. of one brand of tablet contg. zolmitriptan. The results obtained were in agreement with those obtained by published ref. method. The accuracy was also checked by placebo blank and synthetic mixt. analyses besides recovery study via std. addn. procedure. [on SciFinder(R)]
机译:提出了一种准确,准确的分光光度法。唑米曲普坦(ZMT)的制备是基于在浓溶液存在下与香兰素形成红色产物。 H2SO4,色原在580 nm下测量。反应进行定量。在室温下在10分钟内校准曲线在5.0-90.0μgmL-1范围内是线性的,并由回归方程Y =(-)0.0101 + 0.0117X与回归系数描述。 (r)为0.9994(n = 7)。经计算。摩尔吸光度和Sandell灵敏度值分别为3.3×103 Lmol-1cm-1和0.0872μgcm-2。计算了检出限(LOD)和定量(LOQ)。根据ICH指南分别为1.26和3.81μgmL-1。以相对误差表示的日内精度优于1.78%,精度(RSD)为0.83至1.45%。日间准确性介于1.21至1.84%之间,准确性小于1.66%。该方法已成功应用于肛门。一个品牌的平板电脑续集。佐米曲普坦。获得的结果与已发表参考文献的结果一致。方法。还通过安慰剂空白和合成混合物检查了准确性。除了通过std进行恢复研究以外,还进行分析。地址程序。 [在SciFinder(R)上]

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