'ジセイ, ヒカリ ショクバイ オヨビ コウネツ ナノ リュウシ ノ カイハツ ト ヒョウカ オヨビ ガン チリョウ エノ オウヨウ'

摘要

In this thesis, we present a series of different novel experimental techniques for the synthesis of various magnetic, photocatalytic and photothermal nanoparticles with the aim of using them to cancer therapy. We adopted HeLa cells as a model to investigate the thermalphotocatalytic cancer cell killing efficiency of as-synthesized nanomaterials. Furthermore, for the first time we assembled and used combined instrumentation modeling of AC (alternating current) magnetic-field induction and photoexcitation. Nanosized neck-structured and rose type nanoplates of three types of iron oxides (Fe_3O_4, γ-Fe_2O_3 and α-Fe_2O_3) were successfully synthesized by a simple hydrothermal decomposition. Furthermore, Fe_3O_4@TiO_2 core-shell nanocomposites were successfully prepared and their thermal-photocatalytic cell killing efficiency was observed. We also synthesized mixed α and γ-Fe_2O_3 nanoparticles and their synergistic toxic effect against HeLa cells were investigated under AC (alternating current) magnetic-fields induction and photoirradiation conditions at room temperature. Besides we prepared three types of iron oxides (Fe_3O_4, γ-Fe_2O_3 and α-Fe_2O_3) by a co-precipitation method and a comparative study was followed in respects of shape, size, structure and other morphological and magnetic properties. We successfully prepared Cu-TiO_2 nanocomposites. The catalytic activity of the Cu-TiO_2 nanocomposites was evaluated by the application to the photocatalytic cancer (HeLa) cell-killing under UV-visible light irradiation. The Cu-TiO_2 nanocomposites showed higher photocatalytic activity than commercial TiO_2 (P25) under the similar experimental conditions. The Ag metal core-TiO_2 shell (Ag@TiO_2) composite nanoclusters with uniform size, shape and core-shell structures were successfully synthesized by a new simple citrate reduction method. The photocatalytic and photothermal cell killing efficiency of colloidal Ag@TiO_2 core-shell nanoclusters was evaluated against cancer (HeLa) cells under UV–vis irradiation. It was found that the Ag@TiO_2 nanoclusters with an adequate Ag ratio to TiO_2 killed more malignant (HeLa) cells by 80% compared to TiO_2 nanoparticles alone. Finally, from the thorough observations during this research tenure it can be concluded that our synthesized various kinds of nanomaterials whether magnetic, photocatalytic or photothermal showed the great potential use in cancer therapy.