Epigenetic reprogramming of cancer cells under embryonic microenvironment

摘要

The idea of epigenetic reprogramming of cancer cells by an embryonic microenvironmentpossesses potential interest from the prospect of both basic science and potential therapeutic strategies.Chick embryo extract (CEE) has been used for the successful expansion of many specific stem cellsand has demonstrated the ability to facilitate DNA demethylation. The current study was conducted tocompare the status of DNA methylation in highly metastatic and less metastatic osteosarcoma cells andto investigate whether CEE may affect the epigenetic regulation of tumor suppressor genes and thuschange the metastatic phenotypes of highly metastatic osteosarcoma cells.