神経線維腫症1型に生じた胃GISTおよびS状結腸神経線維腫の1例

摘要

Gastrointestinal stromal tumor (GIST) of stomach in a neurofibromatosis type 1 (NF1) patient is very rare. We report herein a case of 61-year-old woman of NF1 with gastric GIST and sigmoid colon neurofibroma. Preoperative examinations revealed a gastric submucosal tumor measuring 4 cm on the body of the stomach and an intramural 2.5 cm sized submucosal tumor at the sigmoid colon. Gastric wedge resection and partial sigmoid colon resection were performed. Immunohistochemically, gastric tumor was diagnosed as a GIST, uncommitted type, and colon lesion was diagnosed as a neurofibroma. Further accumulation and molecular analysis of similar cases will be necessary to elucidate the association of NF1 with GISTs.