An Experimental and Clinical Study on the Acute Eye-trouble due to Methyl-alcohol Poisoning

摘要

39 rabbits were taken experimentally to see changes histologically which occur in the optic tissue during 72 hrs. after injection of pure methyl-alcohol solution (25%) into the abdominal cavity at 10c. c. per kg. of weight. On the other hand the clinical process of optical changes was statistically considered together with the findings of the fundus oculi collected from clinical reports in 13 in-patients (26 eyes) of the Chiba University Hospital who suffer from methyl-alcohol poisoning. The experimental and statistical study leads to the following conclusion: (1) In 3 hrs. after the injection there was found dropsy and swelling in the tractus opticus and the medulated nervus fiber of the retina and also an increase of marchi-granula in the fundus oculi, while in 6hrs. after injection swelling was found in the ganglion cells of the retina and destruction in Nisslu27s granula. This shows that optic nervus fiber is suffered from the poisoning prior to the ganglion cells of the retina. Therefore it may be seen that initial signs of the change due to methyl-alcohol Poisoning must first be found in the optic nervus fiber. (2) From both the experiments in 48hrs. and in 2 months by Bielschowskyu27s method the author finds that in the above 2 cases the local seat of disease is in the tractus opticus and neuro-gliose in that locality. (3) the clinical process of eye-trouble due to methyl-alcohol poisoning is classified into 3 stages by Prof. Ito, director of Eye Clinic of Chiba University, which is morphologically approved by the authoru27s histological study for the clioical changes of 39 experimental rabbits from 3hrs. to 2 months.