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Up against the wall: Is yeast cell wall integrity ensured by mechanosensing in plasma membrane microdomains?

机译:靠墙:通过质膜微区的机械传感确保酵母细胞壁的完整性吗?

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摘要

Yeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of antifungal drugs. A set of five membrane-spanning sensors (Wsc1 to Wsc3, Mid2, and Mtl1) detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. We here summarize the latest advances in the structure/function relationship primarily of the Wsc1 sensor and critically review the evidence that it acts as a echanosensor. The relevance and physiological significance of the information obtained for the function of the other CWI sensors, as well as expected future developments, are discussed.
机译:酵母细胞壁完整性(CWI)信号传导是真菌细胞壁合成调控的模型,并为开发抗真菌药物提供了基础。一组五个跨膜传感器(Wsc1至Wsc3,Mid2和Mtl1)检测细胞表面应力,并在细胞壁结构或质膜发生扰动时开始信号传导途径。我们在这里总结了Wsc1传感器在结构/功能关系方面的最新进展,并严格审查了它充当棘皮类传感器的证据。讨论了获得的信息对于其他CWI传感器的功能的相关性和生理意义,以及预期的未来发展。

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