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Evaluation of plasmatic MMP-8, MMP-9, TIMP-1 and MPO levels in obese and lean women

机译:肥胖和肥胖女性血浆MMP-8,MMP-9,TIMP-1和MPO水平的评估

摘要

Objectives: To compare the plasma concentrations of matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-1, MMP-8, and myeloperoxidase (MPO) for obese and lean women. Design and methods: We recruited 30 lean and 36 obese women without comorbidities. The MMP-9, TIMP-1, and MMP-8 levels were measured using enzyme-linked immunosorbent assay (ELISA). MPO activity was assessed by a colorimetric assay. Results: Obese women had higher MMP-9 levels and MMP-9:TIMP-1 ratios than lean women. Conversely, the MMP-8 levels and MMP-8:TIMP-1 ratios in the obese women were significantly lower than those in the lean women despite neutrophil activation, which was assessed by MPO activity., Conclusion: We observed that MMP-9 and MMP-8 had distinct profiles, which suggested that these 2 enzymes play different roles in obesity. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
机译:目的:比较肥胖和瘦弱妇女的血浆基质金属蛋白酶(MMP)-9,MMP组织抑制剂(TIMP)-1,MMP-8和髓过氧化物酶(MPO)的血浆浓度。设计和方法:我们招募了30名没有合并症的瘦女人和36名肥胖女性。使用酶联免疫吸附测定(ELISA)测量MMP-9,TIMP-1和MMP-8的水平。通过比色测定评估MPO活性。结果:肥胖女性比瘦女性具有更高的MMP-9水平和MMP-9:TIMP-1比值。相反,尽管中性粒细胞活化,肥胖妇女的MMP-8水平和MMP-8:TIMP-1比值明显低于瘦妇女,这是通过MPO活性评估的。结论:我们观察到MMP-9和MMP-8具有不同的特征,这表明这两种酶在肥胖中起着不同的作用。 (C)2012加拿大临床化学家学会。由Elsevier Inc.出版。保留所有权利。

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